High-recovery AAV clarification using a multiplexed spiral inertial microfluidic platform

Lab on a Chip 2026 Open access

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Authors: Alexander Bevacqua, Do Hyun Park, Sheryar Khan, Qingxuan Li, Mahsa Hadidi, Jianzhu Chen, Jongyoon Han
DOI: 10.1039/d5lc01050k
Cited by: 1
References: 27

Abstract

and leads to a two-step AAV recovery of ∼74%, exceeding the 40 to 70% clarification recoveries generally reported. Our results support that further optimization and scale-out of the spiral inertial microfluidic system could increase the overall clarification recovery of AAV production processes.

Fields of Study & Subjects

Virus-based gene therapy research Viral Infectious Diseases and Gene Expression in Insects 3D Printing in Biomedical Research

Publication details

Journal / source
Lab on a Chip
Publisher
Royal Society of Chemistry (RSC)
Volume
26
Issue
12
Pages
3810–3824
Publication date
1 January 2026
Language
EN