Intelligent image-activated sorting of large cells enabled by elasto-inertial focusing

Lab on a Chip 2026 Open access

Read full text
Authors: Yuzuki Nagasaka, Akihiro Isozaki, Hiroki Matsumura, Natsumi Tiffany Ishii, Norah Roels, Mina Rassuli, Kelvin C. M. Lee, Walker Peterson, Tianben Ding, Goda Keisuke
DOI: 10.1039/d5lc01143d
Cited by: 3
References: 62

Abstract

, a large microalgal cell species, based on intracellular lipid droplet formation, demonstrating 4.5-fold enrichment of target cells from 11.9% to 53.8% at 128 eps. Our work highlights that IACS based on elasto-inertial focusing enables the sorting of large objects based on high-content real-time image analysis without compromising sorting purity, yield, or event rate.

Fields of Study & Subjects

Microfluidic and Bio-sensing Technologies Piezoelectric Actuators and Control Digital Holography and Microscopy

Publication details

Journal / source
Lab on a Chip
Publisher
Royal Society of Chemistry (RSC)
Volume
26
Issue
6
Pages
2047–2060
Publication date
1 January 2026
Language
EN