A hypoxic microfluidic organoid-on-a-chip system for studying the efficacy of metronidazole-modified nanomaterials against cholangiocarcinoma established within the chip

Lab on a Chip 2026

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Authors: Ao Xie, Zipeng Yao, Qijun Du, Mengjiao Xia, Qinrui Lu, Jiashu Wang, Wenqi Hu, Lin Wu, Chenwei Sun, Youlong Yang, Di Wu, Haijie Hu
+2 more Guohua Wu, Shuqi Wang
DOI: 10.1039/d5lc01198a
Cited by: 1
References: 52

Abstract

This biomimetic organoid chip recapitulates tumor hypoxia to evaluate specific nanotherapeutics for personalized cholangiocarcinoma treatment.

Fields of Study & Subjects

3D Printing in Biomedical Research Cholangiocarcinoma and Gallbladder Cancer Studies Nanoplatforms for cancer theranostics

Publication details

Journal / source
Lab on a Chip
Publisher
Royal Society of Chemistry (RSC)
Volume
26
Issue
15
Pages
4331–4343
Publication date
1 January 2026
Language
EN