High-throughput bioprinted 3D cultures for probing host–pathogen interactions in bioinspired microenvironments

RSC Applied Polymers 2026 Open access

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Authors: Jodi Graf, DeVonte L. Moore, Catherine Leimkuhler Grimes, Catherine A. Fromen, April M. Kloxin
DOI: 10.1039/d5lp00285k
Cited by: 0
References: 101

Abstract

in stiff microenvironments, with decreased cytokine secretion of IL-6 and IL-1β and elevated IL-10 and TNF-α compared to healthy compliant microenvironments, suggesting that microenvironment properties may shape initial immune responses. This high-throughput, accessible controlled platform provides opportunities for understanding human host-pathogen interactions and a foundation for identifying therapeutic strategies for bacterial infections in well-defined physiologically relevant microenvironments.

Fields of Study & Subjects

3D Printing in Biomedical Research Nanofabrication and Lithography Techniques Cellular Mechanics and Interactions

Publication details

Journal / source
RSC Applied Polymers
Volume
4
Issue
2
Pages
543–556
Publication date
1 January 2026
Language
EN