Biodegradable copper complexing polymeric microparticles relieve oxidative stress

RSC Applied Polymers 2026 Open access

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Authors: Laurel Zhang, Cole Latvis, Xiaokun Jiang, Yadong Wang, Simon Van Herck
DOI: 10.1039/d5lp00289c
Cited by: 1
References: 47

Abstract

a straightforward and scalable co-solvent precipitation method. When chelated with copper(ii) ions, these microparticles (Cu-PASmp) catalytically degrade hydrogen peroxide and protect cells under oxidative stress. Both Cu-PASmp and PASmp demonstrate excellent biocompatibility and elicit no detectable immunogenic response in either M0 or M1 macrophages. Moreover, their presence appears to reduce the need for cells to express superoxide dismutase (SOD1), indicating a decrease in oxidative stress experienced by the cells. Collectively, these results position Cu-PASmp as a promising, catalytic antioxidant platform.

Fields of Study & Subjects

Advanced Nanomaterials in Catalysis Graphene and Nanomaterials Applications Neutrophil Myeloperoxidase and Oxidative Mechanisms

Publication details

Journal / source
RSC Applied Polymers
Publisher
Royal Society of Chemistry (RSC)
Volume
4
Issue
2
Pages
557–567
Publication date
1 January 2026
Language
EN