Synthesis and evaluation of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydromorphinone derivatives: mixed partial agonists at mu opioid and nociception/orphanin FQ peptide receptors

RSC Medicinal Chemistry 2026 Open access

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Authors: Mehrnoosh Ostovar, Keith Olsen, Gerta Cami‐Kobeci, John R. Traynor, Luka Jeramaz, Stewart Brian Kirton, Stephen M. Husbands
DOI: 10.1039/d5md00685f
Cited by: 0
References: 27

Abstract

carbonyl in the naltrexone scaffold to methylene resulted in a balanced MOP:NOP receptor profile in this series, in particular increasing potency at the NOP receptor. Ultimately, this will allow us to determine the optimal profiles for a range of therapeutic indications including pain and drug use disorders.

Fields of Study & Subjects

Neuropeptides and Animal Physiology Alkaloids: synthesis and pharmacology Pain Management and Opioid Use

Publication details

Journal / source
RSC Medicinal Chemistry
Volume
17
Issue
4
Pages
1950–1960
Publication date
1 January 2026
Language
EN