Comprehensive multi-omics analysis and experimental validation indicate that VPS35 is a promising biomarker for prognosis, immunotherapy, and chemotherapy in LIHC

RSC Medicinal Chemistry 2026 Open access

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Authors: Dan Wan, Yajie Qi, Yali Kang, Fanfan Liang, Qian Wang, Hailong Zhang, Shaoying Zhang, X. X. Liang
DOI: 10.1039/d5md00834d
Cited by: 1
References: 47

Abstract

Vacuolar protein sorting 35 ( VPS35 ) is highly expressed in LIHC and exhibits significant diagnostic and prognostic value. Targeted knockdown of VPS35 may inhibit LIHC progression and enhance the efficacy of immunotherapy and chemotherapy.

Fields of Study & Subjects

Nuclear Structure and Function Lung Cancer Treatments and Mutations Clusterin in disease pathology

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
2
Pages
1107–1134
Publication date
1 January 2026
Language
EN