Oxyprenyl–chalcones as antibacterial hits: design of experiments-optimized synthesis, antibacterial evaluation, early drug-like profiling and biodegradability prediction

RSC Medicinal Chemistry 2026 Open access

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Authors: Ludovica Marotta, Francesca Maria Pia Rita Giammarino, Brondon Brandly Senenou Tambou, Valeria Tudino, Stefania Butini, Lorenza Broccardo, Sacha Michèle Idriss Cancade, Jean‐Denis Docquier, Federica Perego, Nicoletta Basilico, Lorenzo Raffellini, Sheraz Gul
+3 more Gabriele Carullo, Sandra Gemma, Giuseppe Campiani
DOI: 10.1039/d5md00839e
Cited by: 0
References: 29

Abstract

against Gram-positive and Gram-negative strains, their toxicological profiles and predicted environmental biodegradability were also assessed. These multifunctional chalcone derivatives demonstrate potential as effective and sustainable antimicrobial agents and the benzofuran derivative 20, the most potent compound of the series, could represent an interesting compound for further optmization.

Fields of Study & Subjects

Synthesis and biological activity Bioactive natural compounds Synthesis of Organic Compounds

Publication details

Journal / source
RSC Medicinal Chemistry
Volume
17
Issue
3
Pages
1573–1585
Publication date
1 January 2026
Language
EN