Parallels between the chloro and methoxy groups for potency optimization
Abstract
There are parallels between Cl and OCH 3 in the types of ligand–protein interactions they engage in. The dual electrostatic versatility of these two substituents renders them useful scouts to probe protein pockets for potency optimization.
Fields of Study & Subjects
Protein Structure and Dynamics
Computational Drug Discovery Methods
Receptor Mechanisms and Signaling
Publication details
- Journal / source
- RSC Medicinal Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 2
- Pages
- 1207–1230
- Publication date
- 1 January 2026
- Language
- EN