Unlocking the therapeutic potential of HDAC8-degrading PROTACs: progress, challenges, and future directions
Abstract
values, showing superior anti-proliferative effects compared to their parent inhibitors. Therefore, apart from these handful of reports, more research related to HDAC8-PROTAC should provide a better therapeutic development technology for HDAC8-associated disorders while avoiding any therapy-related adversities and complications.
Fields of Study & Subjects
Protein Degradation and Inhibitors
Histone Deacetylase Inhibitors Research
HER2/EGFR in Cancer Research
Publication details
- Journal / source
- RSC Medicinal Chemistry
- Volume
- 17
- Issue
- 1
- Pages
- 208–224
- Publication date
- 1 January 2026
- Language
- EN