Dual COX-2 and EGFR inhibition by pyrazole– ar -turmerone hybrids suppresses colorectal cancer cell proliferation

RSC Medicinal Chemistry 2026 Open access

Read full text
Authors: Monsin Sangsawat, Nonthaneth Nalinratana, Waraluck Chaichompoo, Opa Vajragupta, Hua Zhu, Yilin Song, Worathat Thitikornpong, Pornchai Rojsitthisak
DOI: 10.1039/d5md00901d
Cited by: 1
References: 46

Abstract

-turmerone hybrids function as potent dual COX-2/EGFR inhibitors exhibiting selective anti-proliferative activity in inflammation-driven CRC. These compounds represent promising leads for the development of next-generation dual-target therapeutics against colorectal cancer therapy.

Fields of Study & Subjects

Synthesis and bioactivity of alkaloids Synthesis and biological activity Curcumin's Biomedical Applications

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
2
Pages
1000–1014
Publication date
1 January 2026
Language
EN