Exploring pyrazoline-thiophene hybrids as CDK2 inhibitors: synthesis, mechanism, biological studies, and computational insights

RSC Medicinal Chemistry 2026 Open access

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Authors: Heba M. Abosalim, Tarek Elmoselhy, Nabaweya Sharafeldin, Mohamed S. Nafie, Mohamed K. Diab, Mervat H. El‐Hamamsy, Haytham O. Tawfik
DOI: 10.1039/d5md00910c
Cited by: 8
References: 46

Abstract

Novel pyrazoline-linked thiophenes were synthesized as anticancer agents. Lead compound 4p showed sub-micromolar cytotoxicity, induced CDK2-mediated apoptosis and cell-cycle arrest, and reduced tumor burden in vivo with low toxicity.

Fields of Study & Subjects

Synthesis and biological activity Cancer-related Molecular Pathways Synthesis and Characterization of Pyrroles

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
3
Pages
1651–1671
Publication date
1 January 2026
Language
EN