Antibacterial peptidomimetics via fragment display on small-molecule scaffolds

RSC Medicinal Chemistry 2026 Open access

Read full text
Authors: Emma Dyhr, Lucía Cañete De Pinedo, Nicki Frederiksen, Martin S. Bojer, Hanne Ingmer, Ingvill Pedersen Sæbø, Synnøve Brandt Ræder, Magnar Bjoras, Emily Helgesen, James Alexander Booth, Henrik Franzyk
DOI: 10.1039/d5md00916b
Cited by: 1
References: 49

Abstract

) revealed that several compounds possessed an acceptable safety window. These findings highlight the promise of scaffold-based peptidomimetics as novel antibacterial agents and that further studies are warranted.

Fields of Study & Subjects

Biochemical and Structural Characterization Antimicrobial Peptides and Activities Chemical Synthesis and Analysis

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
4
Pages
1989–2001
Publication date
1 January 2026
Language
EN