Novel pyrimido[1,2- a ]imidazole derivatives as potent Pks13-TE inhibitors: structure-based virtual screening and rational design

RSC Medicinal Chemistry 2026 Open access

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Authors: Xiangying Li, Yi Liu, Wen Shao, Deling Jiang, Xupeng Huang, Rao Zihe, Wei Peng, Yuying Fang
DOI: 10.1039/d5md00942a
Cited by: 0
References: 32

Abstract

Integrated virtual and biological screening guided the design and synthesis of 50 novel pyrimido[1,2- a ]imidazole derivatives, leading to the discovery of potent Pks13-TE inhibitor 34 (IC 50 = 0.23 μM).

Fields of Study & Subjects

Protein Kinase Regulation and GTPase Signaling Cell death mechanisms and regulation Protein Tyrosine Phosphatases

Publication details

Journal / source
RSC Medicinal Chemistry
Volume
17
Issue
2
Pages
1066–1082
Publication date
1 January 2026
Language
EN