Discovery of a CHI3L1-targeted small molecule modulating neuroinflammation in Alzheimer's disease via DNA-encoded library (DEL) screening

RSC Medicinal Chemistry 2026

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Authors: Baljit Kaur, Longfei Zhang, Hossam Nada, Laura Calvo-Barreiro, Moustafa Gabr
DOI: 10.1039/d5md00943j
Cited by: 2
References: 30

Abstract

Chitinase-3-like protein 1 (CHI3L1, also known as YKL-40) has emerged as a central effector of astrocyte-mediated neuroinflammation and a promising biomarker for Alzheimer's disease (AD).

Fields of Study & Subjects

Studies on Chitinases and Chitosanases 14-3-3 protein interactions Alzheimer's disease research and treatments

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
4
Pages
1907–1915
Publication date
1 January 2026
Language
EN