Design, synthesis, and molecular modeling of novel thiazolopyridine-based inhibitors of enoyl acyl carrier protein reductase (InhA) as anti- Mycobacterium tuberculosis agents

RSC Medicinal Chemistry 2026 Open access

Read full text
Authors: Ahmed Sabt, Małgorzata Korycka‐Machała, Asmaa F. Kassem, Abdulrahman M. Saleh, Hanaa Farag, Moataz Ahmed Shaldam, Mohamed G. Thabit, Anna M. Brzostek, Magdalena Kuzioła, Bozena R. Dziadek, Hoda Atef Abdelsattar Ibrahim, Xinsheng Lei
+2 more Jarosław Dziadek, Mohamed A. Abdelrahman
DOI: 10.1039/d5md00997a
Cited by: 1
References: 52

Abstract

, demonstrating superior efficacy compared to triclosan, which was employed as the reference drug. Molecular docking and dynamics analyses demonstrated that the pyridine ring and thiazole group are essential for binding affinity, and the pyridine-thiazole framework in compound 5a formed stable interactions within the active site of InhA.

Fields of Study & Subjects

Antimicrobial agents and applications Peptidase Inhibition and Analysis Synthesis and biological activity

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
3
Pages
1586–1599
Publication date
1 January 2026
Language
EN