Discovery of GBA-16-24 as a highly potent, selective ATR inhibitor for the treatment of FLT3-mutated acute myeloid leukemia

RSC Medicinal Chemistry 2026 Open access

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Authors: Ping Li, Haiyan Ren, Xinyan Lan, Junfei Li, Zhi Liu, Huashuo Liu, Zhijie Zheng, Tianyan Zeng, Peili Wang, Mingyang Sun, Lei Xu, Yanyan Zhang
+4 more Yubo Zhou, Jia Li (160557), Mingliang Wang, Kuncai Jiang
DOI: 10.1039/d5md01005e
Cited by: 1
References: 54

Abstract

exhibits synergistic anti-AML effects. Therefore, our findings introduce a promising ATR inhibitor and propose the combination of ATR and FLT3 inhibition as a novel synthetic lethal strategy for treating FLT3-mutated AML.

Fields of Study & Subjects

DNA Repair Mechanisms Cell death mechanisms and regulation Acute Myeloid Leukemia Research

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
4
Pages
2081–2095
Publication date
1 January 2026
Language
EN