Medicinal attributes of nitrogen heterocycles directing aldose reductase selectivity and potency

RSC Medicinal Chemistry 2026 Open access

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Authors: Anita Kumari, Shyamal Kumar Manna, kajal Rani, Rupali Kohal, Ghanshyam Das Gupta, Sant Kumar Verma
DOI: 10.1039/d5md01038a
Cited by: 0
References: 116

Abstract

, and H-bond donor and acceptor properties, influence tissue penetration and pharmacokinetic behavior. Additionally, molecular docking and binding analyses reveal common interaction patterns in the anion-binding and specificity pockets of ALR2, providing mechanistic insight into heterocycle-mediated inhibition. Overall, this review identifies design trends and limitations in nitrogen heterocycle-based ARIs, offering valuable guidance for structure-guided drug design of selective, potent, and clinically therapeutic agents for managing diabetic complications.

Fields of Study & Subjects

Aldose Reductase and Taurine Carbohydrate Chemistry and Synthesis Enzyme function and inhibition

Publication details

Journal / source
RSC Medicinal Chemistry
Volume
17
Issue
3
Pages
1445–1473
Publication date
1 January 2026
Language
EN