Discovery of dihydrospiro[cyclopropane-1,7′-pyrrolo[3,4- d ]pyrimidine] derivatives as novel ATR inhibitors

RSC Medicinal Chemistry 2026 Open access

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Authors: Xiaozhen Chen, Yunbo Qian, Yitong Guo, Junfei Li, Lei Xu, Xingxing Zeng, Kuncai Jiang, Yubo Zhou, Jia Li, Tao Liu
DOI: 10.1039/d5md01127b
Cited by: 0
References: 17

Abstract

synergistically enhanced antiproliferative effects against Granta-519. These results suggested that 10h holds promise for further development as a lead compound for the design of ATR kinase-targeted therapies.

Fields of Study & Subjects

Heterocyclic Compound Synthesis and Bioactivity Synthesis and Characterization of Heterocyclic Compounds Synthesis and pharmacology of benzodiazepine derivatives

Publication details

Journal / source
RSC Medicinal Chemistry
Volume
17
Issue
4
Pages
2067–2080
Publication date
1 January 2026
Language
EN