Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1 H )-quinoline- O -carbamate derivatives as AChE/MAO-B dual inhibitors for the treatment of Alzheimer's disease

RSC Medicinal Chemistry 2026 Open access

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Authors: Wanting Fu, Keren Wang, Hongsong Chen, Tao Liu, Xiaojuan Liu, Qishun Jin, Zhenghuai Tan, Wu Dong, Wenmin Liu, Zhi-Pei Sang
DOI: 10.1039/d5md01138h
Cited by: 0
References: 28

Abstract

-induced zebrafish AD model by elevating ACh, decreasing APP and inflammatory factors. Further, 3c effectively alleviated the scopolamine-induced cognitive impairment model. Therefore, 3c is a promising AChE/MAO-B dual inhibitor for treating AD.

Fields of Study & Subjects

Cholinesterase and Neurodegenerative Diseases Alzheimer's disease research and treatments Heterocyclic Compound Synthesis and Bioactivity

Publication details

Journal / source
RSC Medicinal Chemistry
Volume
17
Issue
4
Pages
2096–2112
Publication date
1 January 2026
Language
EN