A halogenated pregnenolone analogue suppresses HepG2 proliferation and induces apoptosis via PPARγ regulation

RSC Medicinal Chemistry 2026 Open access

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Authors: Shi-Ying Xu, Quan‐Xing Liu, Yan Luo, Wu-He Wu, Q Z Li, Xing-Fu Liu, Jun-Li Ao, An-Ran Fan, Jun-Li Ao, Guo‐Bo Xu
DOI: 10.1039/d5md01142f
Cited by: 0
References: 42

Abstract

Halogenated pregnenolone derivative 20 exerts potent anti-HepG2 effects by inhibiting proliferation and inducing apoptosis through PPARγ modulation.

Fields of Study & Subjects

Peroxisome Proliferator-Activated Receptors Heterocyclic Compound Synthesis and Bioactivity Computational Drug Discovery Methods

Publication details

Journal / source
RSC Medicinal Chemistry
Volume
17
Issue
3
Pages
1493–1512
Publication date
1 January 2026
Language
EN