Structure-based design of potent pyrazolo[1,5- a ]pyrimidine CDK4/6 inhibitors: biological evaluation and computational validation

RSC Medicinal Chemistry 2026 Open access

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Authors: Faizah A. Binjubair, Mahmoud S. Elkotamy, Amr A. Mattar, Bjad K. Almutairy, Sara T. Al‐Rashood, Mohamed M. Eldesouki, Jalloul Bouajila, Hatem A. Abdel-Aziz, Mariam M. Fakhry
DOI: 10.1039/d5md01147g
Cited by: 1
References: 53

Abstract

Structure-based design yielded potent CDK4/6 inhibitor 19i, inducing G1 cell-cycle arrest and apoptosis in HCT-116 cells, supported by enzymatic inhibition and molecular docking/dynamics studies.

Fields of Study & Subjects

Advanced Breast Cancer Therapies Cancer-related Molecular Pathways Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
5
Pages
2566–2587
Publication date
1 January 2026
Language
EN