Design, synthesis and exploration of cyclic imides as PDE4 inhibitors in psoriasis

RSC Medicinal Chemistry 2026 Open access

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Authors: Veena K S, Pallabi Panja, Tirtha Nath, V. G. M. Naidu, Kalyan Kumar Sethi
DOI: 10.1039/d5md01165e
Cited by: 1
References: 59

Abstract

Twenty cyclic imide derivatives were synthesized and tested for their PDE4B inhibition potential. The best molecule selected was further evaluated for its anti-inflammatory property in vitro and PDE4B selectivity in silico .

Fields of Study & Subjects

Phosphodiesterase function and regulation Psoriasis: Treatment and Pathogenesis Macrophage Migration Inhibitory Factor

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
4
Pages
1968–1988
Publication date
1 January 2026
Language
EN