New series of pentamidine-based 1,2,3-triazole-diaryl-hydrazones: design, synthesis, and evaluation of their leishmanicidal activity and mechanism of action against Leishmania (L.) amazonensis

RSC Medicinal Chemistry 2026 Open access

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Authors: Patrícia Ferreira Espuri, Vanessa Silva Gontijo, Laiane M Tavares, Leonardo M Souza, Thalles Henrique Faria de Souza, Dyecika Souza Couto, Juliana Barbosa Nunes, Catarina Azevedo Ribeiro, Sara M. M. Cravo, Bruno Zavan, Marina Amaral Alves, Hygor M. R. de Souza
+5 more Marisa Ionta, Maria Emília Sousa, Eduardo de Figueiredo Peloso, Marcos José Marques, Viegas Junior Claudio
DOI: 10.1039/d5md01174d
Cited by: 0
References: 54

Abstract

levels (+18.9%), suggesting a distinct oxidative profile from the other analogues. These findings highlight the leishmanicidal potential of these three analogues, especially PQM-250, which targets vital parasite survival mechanisms, while exhibiting lower mammalian toxicity. The study provides valuable insights into the metabolic pathways affected by these compounds, offering a strong foundation for developing safer therapeutic strategies against leishmaniasis.

Fields of Study & Subjects

Research on Leishmaniasis Studies Synthesis and Characterization of Heterocyclic Compounds Heterocyclic Compound Synthesis and Bioactivity

Publication details

Journal / source
RSC Medicinal Chemistry
Volume
17
Issue
4
Pages
2157–2169
Publication date
1 January 2026
Language
EN