Structure–activity landscape of Nurr1 (NR4A2) modulators: medicinal chemistry strategies for neurodegenerative disease intervention

RSC Medicinal Chemistry 2026 Open access

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Authors: Sahil Jaidka, Ankush Kumar, Thakur Gurjeet Singh, Rohit Bhatia, Rajesh Kumar Singh
DOI: 10.1039/d5md01177a
Cited by: 2
References: 83

Abstract

Nurr1 modulators show promise for neurodegenerative diseases by improving neuroprotection and suppressing neuroinflammation. This review summarizes scaffold-based SAR and highlights challenges in NR4A selectivity and CNS translation.

Fields of Study & Subjects

Nuclear Receptors and Signaling Nerve injury and regeneration Parkinson's Disease Mechanisms and Treatments

Publication details

Journal / source
RSC Medicinal Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
3
Pages
1369–1396
Publication date
1 January 2026
Language
EN