Rational design of DNA nanocarriers via sequence and length modulation of linker and lock domains: insights from coarse-grained simulations
Abstract
Lock length and sequence composition jointly program the thermal stability, unlocking kinetics, and cargo-release behavior of DNA origami nanocarriers.
Fields of Study & Subjects
Advanced biosensing and bioanalysis techniques
RNA Interference and Gene Delivery
DNA and Nucleic Acid Chemistry
Publication details
- Journal / source
- Molecular Systems Design & Engineering
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 11
- Issue
- 3
- Pages
- 292–304
- Publication date
- 1 January 2026
- Language
- EN