Supramolecular net-suppressor drives tumor vascular-immune microenvironment remodeling with spatiotemporal synchronization for renal cancer therapy

Materials Horizons 2026

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Authors: Lu Wang, Xiao Jin, Xiuhai Wu, Yu Wang, Xi Sun, Jiaye Li, Yue Teng, Yishuo Yan, Cong Li, Yulin Lv, Lingrui Jian, Kaiqiang Yuan
+1 more Lu Wang
DOI: 10.1039/d5mh01936b
Cited by: 1
References: 30

Abstract

Our RING strategy employs a cyclic peptide integrating three modules: (i) dual VEGF/Tie2 targeting for vascular remodeling; (ii) a β-sheet self-assembly motif forming nanofibers; (iii) a D-TIGIT blocking peptide to restore anti-tumor immunity.

Fields of Study & Subjects

Angiogenesis and VEGF in Cancer Renal cell carcinoma treatment Cancer Research and Treatments

Publication details

Journal / source
Materials Horizons
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
8
Pages
4056–4071
Publication date
1 January 2026
Language
EN