Bioadhesive polydopamine-vitamin A derivative hydrogels reprogram the wound microenvironment for scarless wound healing and hair follicle regeneration

Materials Horizons 2026

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Authors: Kang Wang, Hengjie Zhang, Mengxin Wang, Zhengyong Li, Wu Wu, Peng-cheng Liu, Ruiqi Liu, Zhipeng Gu, Yiwen Li, Zhenyu Zhang
DOI: 10.1039/d5mh02076j
Cited by: 8
References: 62

Abstract

hair follicle formation, indicating true functional tissue restoration. Transcriptomic and immunofluorescence analyses further revealed downregulation of pro-fibrotic and inflammatory pathways alongside activation of regenerative signaling, including M2 macrophage polarization and suppression of the M1 phenotype in treated wounds. This study introduces an early vitamin A-based nanocomposite hydrogel with dual anti-scarring and regenerative functions, offering a promising strategy for advanced wound care.

Fields of Study & Subjects

Wound Healing and Treatments Hair Growth and Disorders Corneal Surgery and Treatments

Publication details

Journal / source
Materials Horizons
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
7
Pages
3489–3506
Publication date
1 January 2026
Language
EN