A nanofibrous bacterial cellulose–carboxymethyl cellulose composite with high wet strength and active ester-mediated stable tissue adhesion in dynamic environments
Abstract
-hydroxysuccinimide (NHS) ester and citric acid crosslinks enable rapid covalent bonding with tissue surfaces. This combination yields fast wet adhesion (∼10 s), high shear strength on skin and heart tissues (∼25 kPa), and exceptional fatigue resistance, maintaining interfacial integrity over more than 300 deformation cycles. The BC/CMC tissue adhesive also supports long-term cell viability, confirming its cytocompatibility. Furthermore, kirigami-inspired laser-cut designs enable conformal, strain-accommodating adhesion on highly compliant tissues such as the lungs. Together, this natural polymer hybrid strategy provides a versatile and biocompatible platform for reliable sealing and repair on wet, dynamically moving biological surfaces.
Fields of Study & Subjects
Surgical Sutures and Adhesives
Advanced Cellulose Research Studies
Electrospun Nanofibers in Biomedical Applications
Publication details
- Journal / source
- Materials Horizons
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 13
- Issue
- 9
- Pages
- 4546–4558
- Publication date
- 1 January 2026
- Language
- EN