Bone-targeted calcification-photothermal nanoplatform for synergistic tumor ablation and bone regeneration in breast cancer bone metastasis

Materials Horizons 2026

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Authors: Zhili Ran, Xinyi Li, Guibo Lu, Jiapeng Dong, Yaoxun Zeng, Junze Tang, Huiling Ye, Guining Cao, Yikun Shang, Ziyue Li, Qionge Sun, Xiang Su
+2 more Yan He, Liu Xujie
DOI: 10.1039/d5mh02334c
Cited by: 1
References: 54

Abstract

release, further enhancing calcification and inducing widespread tumor cell death. Laser treatment promotes osteoblast differentiation, supporting bone regeneration. In a murine breast cancer bone metastasis model, the combined calcification-photothermal therapy markedly suppressed tumor burden, mitigated osteolytic lesions, and promoted new bone formation. Together, these findings establish CPPA NPs as a promising therapeutic platform capable of integrating potent antitumor efficacy with osteogenic regeneration, offering a dual-functional strategy for the treatment of breast cancer bone metastasis.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Bone health and treatments Biomarkers in Disease Mechanisms

Publication details

Journal / source
Materials Horizons
Publisher
Royal Society of Chemistry (RSC)
Volume
13
Issue
9
Pages
4590–4605
Publication date
1 January 2026
Language
EN