Multimodal radiosensitization by hafnium oxide nanoparticles and HDAC inhibitors: mechanistic insights

Nanoscale Advances 2026 Open access

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Authors: Csenge Bocz, Dóra Izabella Adamecz, Krisztina Szöke, Bálint Péntek, Emília Rita Szabó, R. Polanek, Titanilla Szögi, Andrea Rónavári, Katalin Hidéghety, Zoltan Konya, Nóra Igaz, Mónika Kiricsi
DOI: 10.1039/d5na00845j
Cited by: 2
References: 59

Abstract

NPs and the tested HDAC inhibitor form a remarkably efficient cancer-selective radiosensitizing combination, where the enzyme inhibitor facilitates the irradiation-induced DNA-damaging potential of the nanoparticles. This outstanding multimodal approach can target radioresistant cancer cells, while not affecting healthy cells, underscoring its potential in a next-generation nanomedicine-based radiosensitizing strategy to attenuate cancer cell growth for an improved therapeutic outcome.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Radiation Therapy and Dosimetry Histone Deacetylase Inhibitors Research

Publication details

Journal / source
Nanoscale Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
8
Issue
6
Pages
2003–2020
Publication date
1 January 2026
Language
EN