Synthesis of azole-linked s -triazine-isatin molecular architectures as nanoscale DNA-targeting agents: a combined spectroscopic and computational study

Nanoscale Advances 2026 Open access

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Authors: Alia Mushtaq, Bibi Nazia, Muhammad Moazzam Naseer
DOI: 10.1039/d5na01140j
Cited by: 1
References: 77

Abstract

Azole-linked s -triazine-isatin hybrids 9a–f exhibit nanoscale groove binding to DNA and strong topoisomerase II interactions. Integrated spectroscopy and simulations identify 9f as a promising DNA-targeted anticancer scaffold.

Fields of Study & Subjects

Synthesis and Characterization of Heterocyclic Compounds Synthesis and Reactivity of Heterocycles Synthesis and biological activity

Publication details

Journal / source
Nanoscale Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
8
Issue
10
Pages
3256–3269
Publication date
1 January 2026
Language
EN