Enhanced stability and sustained delivery of structurally dense DNA nanostructures via a biodegradable hydrogel platform

Nanoscale Horizons 2026 Open access

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Authors: Y. J. Choi, Yeonju Song, Bo Kyung Cho, S J Baek, J. Wang, Su Hyun Seok, William M. Shih, Junsang Doh, Youngmee Jung, Ju Hee Ryu
DOI: 10.1039/d5nh00846h
Cited by: 2
References: 33

Abstract

subcutaneous administration further confirmed that the hybrid system maintained detectable fluorescence for 10 days, significantly outperforming free SQBs, which were cleared within 24 hours. These findings establish a versatile hydrogel framework that effectively serves as a sustained depot for complex DNA nanostructures, offering a generalizable strategy for their localized and long-term deployment in therapeutic applications.

Fields of Study & Subjects

Advanced biosensing and bioanalysis techniques RNA Interference and Gene Delivery Gold and Silver Nanoparticles Synthesis and Applications

Publication details

Journal / source
Nanoscale Horizons
Publisher
Royal Society of Chemistry (RSC)
Volume
11
Issue
4
Pages
1035–1047
Publication date
1 January 2026
Language
EN