Design and synthesis of 2,4-disubstituted thiazole amide derivatives as potential anti-schizophrenia agents

New Journal of Chemistry 2026

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Authors: Donglei Chen, Meiqi Shi, Jun Li, Qiuyu Xiong, Qingkun Wu, Lu Zheng
DOI: 10.1039/d5nj04149j
Cited by: 2
References: 33

Abstract

The synthesized 2,4-disubstituted thiazole amides showed activity in an MK-801 mouse model. Effective derivatives exhibited significant GPR52 agonist activity, marking them as promising anti-schizophrenia candidates.

Fields of Study & Subjects

Receptor Mechanisms and Signaling Neurotransmitter Receptor Influence on Behavior Phosphodiesterase function and regulation

Publication details

Journal / source
New Journal of Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
50
Issue
7
Pages
3112–3122
Publication date
1 January 2026
Language
EN