Discovery, engineering, and applications of amino acid and peptide prenyltransferases
Abstract
Covering: up to 2025Amino acid and peptide prenylation leads to a large variety of natural products, including neurotoxins, alkaloids and (non-)ribosomal peptides, with potent bioactivities. The key biosynthetic enzymes are structurally diverse prenyltransferases, which attach short, linear prenyl donors to amino acid acceptor substrates, and show impressive regio- and chemo-selectivity. The emerging number of characterized prenyltransferases, along with their scope, promiscuity, and engineering, provides an expanded chemoenzymatic toolbox for amino acid prenylation and peptide late-stage functionalization with potential in industrial applications such as peptide-based drug development.
Fields of Study & Subjects
Chemical Synthesis and Analysis
Microbial Natural Products and Biosynthesis
Peptidase Inhibition and Analysis
Publication details
- Journal / source
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 43
- Issue
- 3
- Pages
- 415–426
- Publication date
- 1 January 2026
- Language
- EN