Nitrogen-doped hollow carbon nanospheres as a delivery platform enhance the availability and therapeutic efficacy of curcumin in inflammatory bone defect repair
Abstract
, LPS inhibited bone remodeling and increased the heme oxygenase-1 levels in cranial bone defects. N-HCSO-Cur effectively increased bone remodeling caused by LPS. Overall, the N-HCSO-Cur protective effects of lowering ROS levels and improving BMSC osteogenesis make it a promising novel therapeutic strategy for inflammatory bone defects. Its drug carrier, N-HCSO, is also suitable for loading other poorly soluble drugs.
Fields of Study & Subjects
Bone Tissue Engineering Materials
Curcumin's Biomedical Applications
Bone Metabolism and Diseases
Publication details
- Journal / source
- Nanoscale
- Volume
- 18
- Issue
- 9
- Pages
- 4988–5000
- Publication date
- 1 January 2026
- Language
- EN