A lung-targeted self-assembled supramolecular nanofiber for synergistic therapy of idiopathic pulmonary fibrosis

Nanoscale 2026

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Authors: Jiaxi Han, Taotian Zhang, Yilin Jiang, Tianyuan Chen, Jiawei Lu, Zhenkang Diao, Qing Lin, Shiqi Huang, Ling Zhang
DOI: 10.1039/d5nr04194e
Cited by: 1
References: 33

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic options and high mortality rates. Supramolecular nanofibres RPA@BV targeting the lungs achieve combined therapy for IPF by synergistically releasing BIBF and VS-6766 to inhibit fibroblast activation.

Fields of Study & Subjects

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Proteoglycans and glycosaminoglycans research Nanoplatforms for cancer theranostics

Publication details

Journal / source
Nanoscale
Publisher
Royal Society of Chemistry (RSC)
Volume
18
Issue
10
Pages
5255–5266
Publication date
1 January 2026
Language
EN