Long-term exposure to nanoparticles alters senescence-associated markers and immune responses in human monocyte-derived macrophages

Nanoscale 2026 Open access

Read full text
Authors: Henry C. Lee, Moritz P. Haffner, Sandor Balog, Patricia Taladriz‐Blanco, Aurélien Mroczek, Simona Staudinger, Alke Petri‐Fink, Barbara Rothen‐Rutishauser
DOI: 10.1039/d5nr05035a
Cited by: 0
References: 67

Abstract

: Our findings underscore the need to characterize long-term NP behavior in biological systems and reveal material-specific effects on macrophage senescence-associated traits and immune function. Rather than assessing NP-induced senescence, this study defines how prolonged NP exposure modulates selected senescence-associated signatures in non-proliferative macrophages, offering valuable insights into the functional consequences of chronic NP accumulation.

Fields of Study & Subjects

Nanoparticles: synthesis and applications Telomeres Telomerase and Senescence Immunotoxicology and immune responses

Publication details

Journal / source
Nanoscale
Volume
18
Issue
10
Pages
5517–5530
Publication date
1 January 2026
Language
EN