Rongalite as a mild reductant for solvent-assisted dechlorination of 3,3-dichlorooxindoles to 3-chloro-2-oxindoles and 2-oxindoles

Organic & Biomolecular Chemistry 2026

View at publisher
Authors: Swathi Jalagam, Hari Prasad Kokatla, Sivaparwathi Golla, Nagaraju Naddi
DOI: 10.1039/d5ob01526j
Cited by: 2
References: 80

Abstract

A mild, metal-free, and solvent-controlled reductive dechlorination method has been developed for synthesizing 3-chloro-2-oxindoles, and 2-oxindoles from 3,3-dichlorooxindoles. In this process, Rongalite serves as a mild reducing agent, achieving monodechlorination in polar protic, and complete dehalogenation in polar aprotic solvents, leading to the formation of 3-chloro-2-oxindoles, and oxindoles, respectively. This methodology features several advantages, including the use of inexpensive reagents, mild reaction conditions, simple operational procedures, high yields, and short reaction times.

Fields of Study & Subjects

Environmental remediation with nanomaterials Vanadium and Halogenation Chemistry Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
4
Pages
911–920
Publication date
1 January 2026
Language
EN