Iron-catalyzed oxidative cleavage of C–N bonds of tertiary amines: syntheses of unsymmetrical ureas from isocyanates
Abstract
as the catalyst and aqueous TBHP as a benign oxidant in acetonitrile, enabling tertiary anilines to react with various isocyanates at room temperature. The protocol features a broad substrate scope and excellent functional group tolerance, while being operationally simple and scalable. It thus offers a practical and sustainable alternative for the synthesis of ureas.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Carbon dioxide utilization in catalysis
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Volume
- 24
- Issue
- 4
- Pages
- 905–910
- Publication date
- 1 January 2026
- Language
- EN