Silver catalyzed cascade cyclization of 2-(allyloxy)arylaldehydes: synthesis of chroman-4-one derivatives
Abstract
Herein, a novel cascade cyclization for the synthesis of oxyalkylated and 1,5-dicarbonylated chroman-4-ones from 2-(allyloxy)arylaldehydes is described. The transformation proceeded in the presence of a silver salt to generate a series of anticipated chroman-4-one derivatives in moderate to good yields, and the alcohols or ketones in this reaction were employed as both reaction media and oxyalkyl or carbonyl sources, exhibiting an atom-economical approach for the preparation of chroman-4-one skeletons.
Fields of Study & Subjects
Organic Chemistry Synthesis Methods
Catalytic Alkyne Reactions
Asymmetric Synthesis and Catalysis
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Volume
- 24
- Issue
- 6
- Pages
- 1237–1241
- Publication date
- 1 January 2026
- Language
- EN