Radical-promoted cyclization of 3-allyl-2-arylquinazolinones mediated by silver( i ) salts to access SCF 3 /SCN-enriched dihydroisoquinolino[1,2- b ]quinazolinones
Abstract
]quinazolinones through radical-mediated thio-functionalization of allylic alkenes followed by intramolecular cyclization. The transformation proceeds through sulfur-radical-triggered C-S and C-C bond formation, providing an efficient route to sulfur- and fluorine-enriched polycyclic quinazolinones. Moreover, this strategy offers high atom economy, operational simplicity, and broad substrate compatibility.
Fields of Study & Subjects
Quinazolinone synthesis and applications
Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 6
- Pages
- 1263–1267
- Publication date
- 1 January 2026
- Language
- EN