Cu-catalyzed oxidative imino Diels–Alder cyclization: synthesis of dihydrofuroquinolines

Organic & Biomolecular Chemistry 2026

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Authors: Vikash Kumar, Ashutosh Dey, Rohit Kumar Maurya, Abhay Kumar Yadav, Megha Kumari, Angad Kumar Singh, Mahender Khatravath
DOI: 10.1039/d5ob01758k
Cited by: 1
References: 34

Abstract

]quinolines. This method employs inexpensive and readily available substrates and proceeds through sequential imine formation, intramolecular [4 + 2] cycloaddition, and oxidative aromatization, while tolerating a broad range of functional groups. Oxone acts as a green and cost-effective oxidant, affording the desired products in high yields. Furthermore, subsequent benzylic oxidation enables efficient conversion of dihydrofuroquinolines into quinoline-fused lactones, which are valuable intermediates in natural product synthesis.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Alkyne Reactions Traditional and Medicinal Uses of Annonaceae

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
8
Pages
1659–1665
Publication date
1 January 2026
Language
EN