Iron-catalyzed radical reactions: recent progress in organic synthesis
Abstract
halogen abstraction or single-electron transfer (SET) and functions as a bifunctional Lewis acid through Fe-σ and Fe-π interactions, further broadening its reactivity. These features have expanded applications in pharmaceuticals, natural products, and functional materials. Coupling iron catalysis with photoredox methods enhances both reaction scope and sustainability. This review surveys recent advances in cross-coupling, C-H functionalization, cyclization, decarboxylation, amination, and heterocycle synthesis, organized by radical generation strategies, and concludes with perspectives on future developments.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 8
- Pages
- 1562–1594
- Publication date
- 1 January 2026
- Language
- EN