BF 3 ·Et 2 O-catalyzed dearomative spirocyclization of ynones for the synthesis of spirolactams and spirolactones
Abstract
O catalyzed intramolecular cyclization reaction of ynones, enabling the efficient synthesis of spiro-heterocyclic compounds, such as spiro-γ-lactams and spiro-γ-lactones. This reaction enables the synthesis of diverse spirocyclic compounds under metal-free and mild conditions, exhibiting broad substrate compatibility and excellent yields.
Fields of Study & Subjects
Catalytic Alkyne Reactions
Catalytic C–H Functionalization Methods
Oxidative Organic Chemistry Reactions
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 24
- Issue
- 4
- Pages
- 820–823
- Publication date
- 1 January 2026
- Language
- EN