Design, synthesis, and structural analysis of an inhibitor of the gastric proton pump with a diaza-tricyclic skeleton

Organic & Biomolecular Chemistry 2026 Open access

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Authors: Nariyoshi Umekubo, Airi Hashizume, Haruki Saito, Satoru Kato, Chisato Kanai, Chai C. Gopalasingam, Christoph Gerle, Hideki SHIGEMATSU, Atsushi Yoshimori, Kazuhiro Abe, Satoshi Yokoshima
DOI: 10.1039/d5ob01828e
Cited by: 1
References: 24

Abstract

A rigid and three-dimensional skeleton has been designed and synthesized for novel K + -competitive acid blokers.

Fields of Study & Subjects

Gastroesophageal reflux and treatments Molecular Sensors and Ion Detection Pharmacological Receptor Mechanisms and Effects

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
5
Pages
1000–1005
Publication date
1 January 2026
Language
EN