Design and assessment of dimeric trehalose glycolipids as a strategy to enhance Mincle-mediated vaccine adjuvanticity

Organic & Biomolecular Chemistry 2026

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Authors: Emma M. Dangerfield, M. A. Thathsaranie P. Manthrirathna, James C. Robinson, Brenda S. Luong, Olga R Palmer, Lisa M. Connor, Mattie S. M. Timmer, Bridget L. Stocker
DOI: 10.1039/d5ob01835h
Cited by: 1
References: 45

Abstract

using OVA as a model antigen and was found to induce significantly more germinal centre B cells compared to OVA alone and TDB + OVA (unconjugated); however neither TDB nor dimer 3b led to an increase in T cell numbers relative to OVA alone. Taken together, these data provide proof of concept that dimeric Mincle ligands are a new class of potential Mincle-mediated vaccine adjuvants.

Fields of Study & Subjects

Immunotherapy and Immune Responses Glycosylation and Glycoproteins Research Transgenic Plants and Applications

Publication details

Journal / source
Organic & Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Volume
24
Issue
9
Pages
1822–1836
Publication date
1 January 2026
Language
EN