Regioselective multicomponent synthesis of α-boryl ureas: discovery of a potent main protease inhibitor

Organic & Biomolecular Chemistry 2026 Open access

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Authors: Yusif I Gyasi, Satyanarayana Nyalata, Sophea Pa, Disni Gunasekera, Veerabhadra R. Vulupala, N. Arjunreddy Mallampudi, Ramidi Gopal Reddy, Shiqing Xu
DOI: 10.1039/d5ob01846c
Cited by: 0
References: 66

Abstract

= 12 nM) against the SARS-CoV-2 main protease. This work not only provides a streamlined and practical synthetic route to diverse α-boryl ureas, but also underscores their potential as valuable scaffolds in the development of new therapeutics.

Fields of Study & Subjects

Organoboron and organosilicon chemistry Click Chemistry and Applications Multicomponent Synthesis of Heterocycles

Publication details

Journal / source
Organic & Biomolecular Chemistry
Volume
24
Issue
5
Pages
1033–1041
Publication date
1 January 2026
Language
EN