Synthetic approach toward the indole alkaloid TMC-205, 6,7-secoagroclavine, aurantioclavine, clavicipitic acid, and caulindoles A–D
Abstract
-isomer). This synthesis protocol is protecting group-free, redox neutral, environmentally benign, and features simple operation steps. Through the implementation of this new, efficient and scalable synthesis method, the formal synthesis of a series of novel meroterpenoid natural products can be successfully realized. Moreover, the synthetic strategy and methodologies demonstrated in this paper are useful and can be easily extended to the preparation of other related biologically active molecules.
Fields of Study & Subjects
Advanced Synthetic Organic Chemistry
Synthesis of Indole Derivatives
Synthesis and bioactivity of alkaloids
Publication details
- Journal / source
- Organic & Biomolecular Chemistry
- Volume
- 24
- Issue
- 10
- Pages
- 2034–2045
- Publication date
- 1 January 2026
- Language
- EN