Enantioselective synthesis of antibiotic inducing gamma-butenolides from Streptomyces rochei and derivatives

Organic & Biomolecular Chemistry 2026 Open access

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Authors: Haylie E. Hennigan, Manuela Frias‐Gomez, Kylie G. Castator, Lauren E. Wilbanks, Caroline Zu, Gracie Sanders, Elizabeth I. Parkinson
DOI: 10.1039/d5ob01862e
Cited by: 0
References: 18

Abstract

A divergent, enantioselective synthesis of quorum sensing molecules and a green-fluorescence protein reporter assay were developed, allowing for identification of key structural features for induction of natural product antibiotics.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Organic Chemistry Synthesis Methods Bacterial biofilms and quorum sensing

Publication details

Journal / source
Organic & Biomolecular Chemistry
Volume
24
Issue
10
Pages
2069–2074
Publication date
1 January 2026
Language
EN